Neuroscience of inhibition for addiction medicine: from prediction of initiation to prediction of relapse.

@article{Moeller2016NeuroscienceOI,
  title={Neuroscience of inhibition for addiction medicine: from prediction of initiation to prediction of relapse.},
  author={Scott J Moeller and Lucia Bederson and Nelly Alia-Klein and Rita Z. Goldstein},
  journal={Progress in brain research},
  year={2016},
  volume={223},
  pages={165-88}
}
A core deficit in drug addiction is the inability to inhibit maladaptive drug-seeking behavior. Consistent with this deficit, drug-addicted individuals show reliable cross-sectional differences from healthy nonaddicted controls during tasks of response inhibition accompanied by brain activation abnormalities as revealed by functional neuroimaging. However, it is less clear whether inhibition-related deficits predate the transition to problematic use, and, in turn, whether these deficits predict… CONTINUE READING

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