Neuroscience of apathy and anhedonia: a transdiagnostic approach

@article{Husain2018NeuroscienceOA,
  title={Neuroscience of apathy and anhedonia: a transdiagnostic approach},
  author={Masud Husain and Jonathan Paul Roiser},
  journal={Nature Reviews Neuroscience},
  year={2018},
  volume={19},
  pages={470-484}
}
  • M. Husain, J. Roiser
  • Published 26 June 2018
  • Psychology, Biology, Medicine
  • Nature Reviews Neuroscience
Apathy and anhedonia are common syndromes of motivation that are associated with a wide range of brain disorders and have no established therapies. Research using animal models suggests that a useful framework for understanding motivated behaviour lies in effort-based decision making for reward. The neurobiological mechanisms underpinning such decisions have now begun to be determined in individuals with apathy or anhedonia, providing an important foundation for developing new treatments. The… 
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211 Citations
Highly Influential Citations
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66
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Results Citations
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211 Citations

Revisiting Apathy in Alzheimer's Disease: From Conceptualization to Therapeutic Approaches
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It is unlikely that a single pharmacological or nonpharmacological strategy will be effective for all cases of apathy in AD, and high-quality evidence research is needed to better understand the role of specific strategies aiming at a personalized approach.
Recommendations for the Nonpharmacological Treatment of Apathy in Brain Disorders.
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    The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry
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Noradrenergic deficits contribute to apathy in Parkinson’s disease through the precision of expected outcomes
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It is proposed that noradrenergic deficits contribute to apathy by modulating the relative weighting of prior beliefs about action outcomes, and tested this hypothesis in the clinical context of Parkinson’s disease, where it was confirmed as negatively correlated with apathy.
Apathy: Neurobiology, Assessment and Treatment
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    Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology
  • 2021
TLDR
The neuropsychology and associated neurobiological underpinnings of apathy in the above conditions are addressed, specific methods to assess apathy clinically are identified, and the literature on managing apathy across these various disorders is reviewed.
Mechanisms Underlying Motivational Dysfunction in Schizophrenia
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Findings in the literature suggest that schizophrenia is characterised by impaired reward based learning and action selection, despite preserved hedonic responses, which is crucial in advancing the understanding of this complex syndrome.
Uncovering the prevalence and neural substrates of anhedonia in frontotemporal dementia.
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This is the first study to document the prevalence and neural correlates of anhedonia in FTD in comparison with Alzheimer's disease, and its potential overlap with related motivational symptoms including apathy and depression, and point to the importance of considering anhedonian as a primary presenting feature of behavioural variant FTD and semantic dementia.
Pharmacologic Approaches for the Management of Apathy in Neurodegenerative Disorders
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Current main levels of evidence have been reported so far with cholinergic, glutamatergic and dopaminergic agents to reduce levels of apathy, despite several conflicting results.
Noradrenergic deficits contribute to apathy in Parkinson's disease through the precision of expected outcomes
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Results indicate a contribution of the noradrenergic system to apathy and potential benefit from norad Renaline reuptake inhibitor treatment of people with Parkinson's disease, subject to stratification according to locus coeruleus integrity.
From apathy to addiction: Insights from neurology and psychiatry
Assessment of apathy in neurological patients using the Apathy Motivation Index caregiver version.
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A brief caregiver questionnaire version of the recently developed Apathy Motivation Index (AMI), which is a self-report tool, which showed good internal reliability, external validity and diagnostic accuracy and uncovered cases of social apathy overlooked by traditional instruments.
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