Neuroscience of apathy and anhedonia: a transdiagnostic approach

@article{Husain2018NeuroscienceOA,
  title={Neuroscience of apathy and anhedonia: a transdiagnostic approach},
  author={Masud Husain and Jonathan Paul Roiser},
  journal={Nature Reviews Neuroscience},
  year={2018},
  volume={19},
  pages={470-484}
}
  • M. Husain, J. Roiser
  • Published 26 June 2018
  • Psychology, Biology, Medicine
  • Nature Reviews Neuroscience
Apathy and anhedonia are common syndromes of motivation that are associated with a wide range of brain disorders and have no established therapies. Research using animal models suggests that a useful framework for understanding motivated behaviour lies in effort-based decision making for reward. The neurobiological mechanisms underpinning such decisions have now begun to be determined in individuals with apathy or anhedonia, providing an important foundation for developing new treatments. The… 
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216 Citations
Highly Influential Citations
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216 Citations

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The neuropsychology and associated neurobiological underpinnings of apathy in the above conditions are addressed, specific methods to assess apathy clinically are identified, and the literature on managing apathy across these various disorders is reviewed.
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Findings in the literature suggest that schizophrenia is characterised by impaired reward based learning and action selection, despite preserved hedonic responses, which is crucial in advancing the understanding of this complex syndrome.
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This is the first study to document the prevalence and neural correlates of anhedonia in FTD in comparison with Alzheimer's disease, and its potential overlap with related motivational symptoms including apathy and depression, and point to the importance of considering anhedonian as a primary presenting feature of behavioural variant FTD and semantic dementia.
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Current main levels of evidence have been reported so far with cholinergic, glutamatergic and dopaminergic agents to reduce levels of apathy, despite several conflicting results.
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References

SHOWING 1-10 OF 248 REFERENCES
The anatomy of apathy: A neurocognitive framework for amotivated behaviour
Impulsivity and apathy in Parkinson's disease.
TLDR
It is argued that there is strong support for a hypodopaminergic state in PD patients with apathy, as well as for an association between dopamine therapy and development of ICDs, and suggested that impulsivity and apathy can arise from dissociable deficits in option generation, option selection, action initiation or inhibition and learning.
Dopamine reverses reward insensitivity in apathy following globus pallidus lesions
Apathy in schizophrenia as a deficit in the generation of options for action.
TLDR
It is shown that the association between measures of psychopathology and option generation is most pronounced in regard to apathy symptoms and that it is only partially mediated by deficits in verbal fluency.
The nosological position of apathy in clinical practice
TLDR
In summary, apathy is increasingly recognised as a common behavioural syndrome associated with neuropsychiatric disorders, but it is conceptually ill defined and there is a need for consensus on diagnostic criteria to facilitate future research.
Reconsidering anhedonia in depression: Lessons from translational neuroscience
Apathy and Anhedonia in Parkinson's Disease
Depression, apathy, and anhedonia are often comorbid in patients with Parkinson's disease. Since the morbid states of apathy and anhedonia are complicated, these symptoms are often difficult to…
Distinct Subtypes of Apathy Revealed by the Apathy Motivation Index
TLDR
The Apathy-Motivation Index (AMI) is a novel and reliable measure of individual differences in apathy and might provide a useful means of probing different mechanisms underlying sub-clinical lack of motivation in otherwise healthy individuals.
Apathy: a neuropsychiatric syndrome.
  • R. Marin
  • Psychology, Medicine
    The Journal of neuropsychiatry and clinical neurosciences
  • 1991
TLDR
Evidence that neuropsychiatric disorders also produce a syndrome of apathy is evaluated, and clinical and investigative approaches for evaluating apathy when it occurs in association with other syndromes are described.
Anhedonia in schizophrenia: a review of assessment strategies.
TLDR
It is concluded that anhedonia can be reliably assessed and constitutes a distinctive, clinically important aspect of schizophrenia that should be included in a comprehensive evaluation of negative symptoms.
...
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