Neuroscience of apathy and anhedonia: a transdiagnostic approach

  title={Neuroscience of apathy and anhedonia: a transdiagnostic approach},
  author={Masud Husain and Jonathan Paul Roiser},
  journal={Nature Reviews Neuroscience},
  • M. Husain, J. Roiser
  • Published 26 June 2018
  • Psychology, Biology, Medicine
  • Nature Reviews Neuroscience
Apathy and anhedonia are common syndromes of motivation that are associated with a wide range of brain disorders and have no established therapies. Research using animal models suggests that a useful framework for understanding motivated behaviour lies in effort-based decision making for reward. The neurobiological mechanisms underpinning such decisions have now begun to be determined in individuals with apathy or anhedonia, providing an important foundation for developing new treatments. The… 
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The neuropsychology and associated neurobiological underpinnings of apathy in the above conditions are addressed, specific methods to assess apathy clinically are identified, and the literature on managing apathy across these various disorders is reviewed.
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The author first summarizes the extant knowledge about the pathophysiology of anhedonia, which may provide a road map toward novel treatment and prevention strategies, and then highlights several priorities to facilitate clinically meaningful breakthroughs.
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Noradrenergic deficits contribute to apathy in Parkinson's disease through the precision of expected outcomes
Results indicate a contribution of the noradrenergic system to apathy and potential benefit from norad Renaline reuptake inhibitor treatment of people with Parkinson's disease, subject to stratification according to locus coeruleus integrity.
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It is argued that there is strong support for a hypodopaminergic state in PD patients with apathy, as well as for an association between dopamine therapy and development of ICDs, and suggested that impulsivity and apathy can arise from dissociable deficits in option generation, option selection, action initiation or inhibition and learning.
Apathy in schizophrenia as a deficit in the generation of options for action.
It is shown that the association between measures of psychopathology and option generation is most pronounced in regard to apathy symptoms and that it is only partially mediated by deficits in verbal fluency.
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In summary, apathy is increasingly recognised as a common behavioural syndrome associated with neuropsychiatric disorders, but it is conceptually ill defined and there is a need for consensus on diagnostic criteria to facilitate future research.
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Depression, apathy, and anhedonia are often comorbid in patients with Parkinson's disease. Since the morbid states of apathy and anhedonia are complicated, these symptoms are often difficult to
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The Apathy-Motivation Index (AMI) is a novel and reliable measure of individual differences in apathy and might provide a useful means of probing different mechanisms underlying sub-clinical lack of motivation in otherwise healthy individuals.
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    The Journal of neuropsychiatry and clinical neurosciences
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Anhedonia in schizophrenia: a review of assessment strategies.
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