Neuroscience of apathy and anhedonia: a transdiagnostic approach
@article{Husain2018NeuroscienceOA, title={Neuroscience of apathy and anhedonia: a transdiagnostic approach}, author={Masud Husain and Jonathan Paul Roiser}, journal={Nature Reviews Neuroscience}, year={2018}, volume={19}, pages={470-484} }
Apathy and anhedonia are common syndromes of motivation that are associated with a wide range of brain disorders and have no established therapies. Research using animal models suggests that a useful framework for understanding motivated behaviour lies in effort-based decision making for reward. The neurobiological mechanisms underpinning such decisions have now begun to be determined in individuals with apathy or anhedonia, providing an important foundation for developing new treatments. The…
211 Citations
Revisiting Apathy in Alzheimer's Disease: From Conceptualization to Therapeutic Approaches
- Psychology, BiologyBehavioural neurology
- 2021
It is unlikely that a single pharmacological or nonpharmacological strategy will be effective for all cases of apathy in AD, and high-quality evidence research is needed to better understand the role of specific strategies aiming at a personalized approach.
Recommendations for the Nonpharmacological Treatment of Apathy in Brain Disorders.
- Medicine, PsychologyThe American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry
- 2019
Noradrenergic deficits contribute to apathy in Parkinson’s disease through the precision of expected outcomes
- Psychology, BiologyPLoS computational biology
- 2022
It is proposed that noradrenergic deficits contribute to apathy by modulating the relative weighting of prior beliefs about action outcomes, and tested this hypothesis in the clinical context of Parkinson’s disease, where it was confirmed as negatively correlated with apathy.
Apathy: Neurobiology, Assessment and Treatment
- Psychology, MedicineClinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology
- 2021
The neuropsychology and associated neurobiological underpinnings of apathy in the above conditions are addressed, specific methods to assess apathy clinically are identified, and the literature on managing apathy across these various disorders is reviewed.
Mechanisms Underlying Motivational Dysfunction in Schizophrenia
- Psychology, BiologyFrontiers in Behavioral Neuroscience
- 2021
Findings in the literature suggest that schizophrenia is characterised by impaired reward based learning and action selection, despite preserved hedonic responses, which is crucial in advancing the understanding of this complex syndrome.
Uncovering the prevalence and neural substrates of anhedonia in frontotemporal dementia.
- Psychology, MedicineBrain : a journal of neurology
- 2021
This is the first study to document the prevalence and neural correlates of anhedonia in FTD in comparison with Alzheimer's disease, and its potential overlap with related motivational symptoms including apathy and depression, and point to the importance of considering anhedonian as a primary presenting feature of behavioural variant FTD and semantic dementia.
Pharmacologic Approaches for the Management of Apathy in Neurodegenerative Disorders
- Psychology, BiologyFrontiers in Pharmacology
- 2019
Current main levels of evidence have been reported so far with cholinergic, glutamatergic and dopaminergic agents to reduce levels of apathy, despite several conflicting results.
Noradrenergic deficits contribute to apathy in Parkinson's disease through the precision of expected outcomes
- PsychologymedRxiv
- 2021
Results indicate a contribution of the noradrenergic system to apathy and potential benefit from norad Renaline reuptake inhibitor treatment of people with Parkinson's disease, subject to stratification according to locus coeruleus integrity.
From apathy to addiction: Insights from neurology and psychiatry
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Assessment of apathy in neurological patients using the Apathy Motivation Index caregiver version.
- Psychology, MedicineJournal of neuropsychology
- 2021
A brief caregiver questionnaire version of the recently developed Apathy Motivation Index (AMI), which is a self-report tool, which showed good internal reliability, external validity and diagnostic accuracy and uncovered cases of social apathy overlooked by traditional instruments.
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