Neurosarcoidosis: signs, course and treatment in 35 confirmed cases.


Thirty-five cases of biopsy-proven sarcoidosis with neurologic manifestations are reported. Neurosarcoidosis was the presenting symptom in 31% of cases and the only clinical manifestation in 17%. Mean follow-up time was 48 months. Central nervous system involvement was observed in 37% and meningitis in 40% of patients. Other manifestations were cranial nerve palsies (37%), peripheral neuropathy (40%), and myopathy (26%). Multiple neurologic manifestations were present in 51% of cases. All but 4 were treated with corticosteroids. Another immunosuppressive agent or cerebral irradiation was added in 6 and 2 patients, respectively. Complete recovery was observed in 46%, improvement in 46%, 4% remained stable, and 4% worsened. There were no deaths. We advocate treating neurosarcoidosis with corticosteroids as early as possible. If the patient's condition worsens, additional immunosuppressive agents or cerebral irradiation is warranted.

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@article{Chapelon1990NeurosarcoidosisSC, title={Neurosarcoidosis: signs, course and treatment in 35 confirmed cases.}, author={Catherine Chapelon and J M Ziza and Jean-charles Piette and Yair Levy and Gilles Raguin and Bertrand Wechsler and Marc-Olivier Bitker and Olivier Bl{\'e}try and Dominique Laplane and M . G . Bousser}, journal={Medicine}, year={1990}, volume={69 5}, pages={261-76} }