Neurorestorative effects of eugenol, a spice bioactive: Evidence in cell model and its efficacy as an intervention molecule to abrogate brain oxidative dysfunctions in the streptozotocin diabetic rat

@article{Prasad2016NeurorestorativeEO,
  title={Neurorestorative effects of eugenol, a spice bioactive: Evidence in cell model and its efficacy as an intervention molecule to abrogate brain oxidative dysfunctions in the streptozotocin diabetic rat},
  author={S. N. Prasad and M. Bharath and Muralidhara},
  journal={Neurochemistry International},
  year={2016},
  volume={95},
  pages={24-36}
}
  • S. N. Prasad, M. Bharath, Muralidhara
  • Published 2016
  • Medicine
  • Neurochemistry International
  • Eugenol (EU), an active principle of cloves, is also widely distributed in various other plants (eg. [...] Key Result Co-exposure of cells with EU (5-10 μM) not only enhanced the cell viability, but significantly offset glucose -associated oxidative stress (as evidenced by diminished levels of reactive oxygen species and hydroperoxides). Further EU enhanced the reduced glutathione (GSH) levels and also ameliorated the levels of 3 - nitrotyrosine and expression of HSP70. We subsequently examined its efficacy to…Expand Abstract
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    References

    SHOWING 1-10 OF 79 REFERENCES
    Neuroprotective Efficacy of Eugenol and Isoeugenol in Acrylamide-Induced Neuropathy in rats: Behavioral and Biochemical evidence
    • 79
    Inhibition of key enzymes related to diabetes and hypertension by Eugenol in vitro and in alloxan-induced diabetic rats
    • 40