Neuroregenerative potential of lion's mane mushroom, Hericium erinaceus (Bull.: Fr.) Pers. (higher Basidiomycetes), in the treatment of peripheral nerve injury (review).

@article{Wong2012NeuroregenerativePO,
  title={Neuroregenerative potential of lion's mane mushroom, Hericium erinaceus (Bull.: Fr.) Pers. (higher Basidiomycetes), in the treatment of peripheral nerve injury (review).},
  author={Kah-Hui Wong and Murali Naidu and Rosie Pamela David and Robiah Bakar and Vikineswary Sabaratnam},
  journal={International journal of medicinal mushrooms},
  year={2012},
  volume={14 5},
  pages={
          427-46
        }
}
We present a model case study of the activity of aqueous extract of Hericium erinaceus fresh fruit bodies in promoting functional recovery following crush injury to the peroneal nerve in adult female Sprague-Dawley rats. The aim was to explore the possible use of this mushroom in nerve repair. The activities of aqueous extract were compared to activities exhibited by mecobalamin (vitamin B12), which has been widely used in the treatment of peripheral nerve disorders. Analysis of walking track… 
Restoration of sensory dysfunction following peripheral nerve injury by the polysaccharide from culinary and medicinal mushroom, Hericium erinaceus (Bull.: Fr.) Pers. through its neuroregenerative action
TLDR
The findings suggest that H. erinaceus is capable of accelerating sensory functional recovery after peripheral nerve injury and the effect involves the activation of protein kinase signaling pathways and restoration of blood-nerve barrier.
Hericium erinaceus (Bull.: Fr) Pers. cultivated under tropical conditions: isolation of hericenones and demonstration of NGF-mediated neurite outgrowth in PC12 cells via MEK/ERK and PI3K-Akt signaling pathways.
TLDR
It is suggested that hericenone E potentiated NGF-induced neuritogenesis in PC12 cells via the MEK/ERK and PI3K/Akt pathways.
Neurological Activity of Lion’s Mane (Hericium erinaceus)
TLDR
Because of its anti-inflammatory properties and promotion of nerve growth factor gene expression and neurite (axon or dendrite) outgrowth, H. erinaceus mycelium shows great promise for the treatment of Alzheimer's and Parkinson’s diseases.
Improvement of erinacine A productivity in Hericium erinaceus mycelia and its neuroprotective bioactivity against the glutamate-insulted apoptosis
TLDR
Whether erinacines can play a role as a neuroprotective adjuvant and what the related mechanism of action could be is uncovered.
Lignosus rhinocerotis (Cooke) Ryvarden mimics the neuritogenic activity of nerve growth factor via MEK/ERK1/2 signaling pathway in PC-12 cells
TLDR
The neuritogenic activity in PC-12 cells stimulated by hot aqueous and ethanolic extracts, and crude polysaccharides of L. rhinocerotis sclerotium mimicking NGF activity via the MEK/ERK1/2 signaling pathway is reported for the first time.
Hericerin derivatives from Hericium erinaceus exert BDNF-like neurotrophic activity in central hippocampal neurons and enhance memory
Abstract The traditional medicinal mushroom Hericium erinaceus has long been known for enhancing the peripheral nerve regeneration through targeting nerve growth factor (NGF) neurotrophic activity.
In vitro anti-neuroinflammatory and neuritogenic stimulatory effects of a medicinal mushroom lignosus rhinocerotis (Cooke) ryvarden / Syntyche Seow Ling Sing
Neuroinflammation and neurite degeneration are contributing factors leading to the progression of neuronal loss and age-related neurodegenerative diseases e.g Alzheimer’s and Parkinson’s disease.
Neurite outgrowth stimulatory effects of myco synthesized AuNPs from Hericium erinaceus (Bull.: Fr.) Pers. on pheochromocytoma (PC-12) cells
TLDR
AuNPs were shown to have potential neuronal differentiation and stimulated neurite outgrowth and the water-soluble bioconstituents could be responsible for the neuroactivity.
Uridine from Pleurotus giganteus and Its Neurite Outgrowth Stimulatory Effects with Underlying Mechanism
TLDR
It is demonstrated that P. giganteus may enhance neurite outgrowth and one of the key bioactive molecules responsible for neuriteOutgrowth is uridine.
Hericium erinaceus, an amazing medicinal mushroom
TLDR
The scientific literature is examined to explore and highlight the scientific facts concerning medicinal properties of H. erinaceus and two classes of terpenoid compounds, hericenones and erinacines, from fruiting bodies and cultured mycelia, respectively, have been found to stimulate nerve growth factor synthesis.
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References

SHOWING 1-10 OF 129 REFERENCES
Peripheral Nerve Regeneration Following Crush Injury to Rat Peroneal Nerve by Aqueous Extract of Medicinal Mushroom Hericium erinaceus (Bull.: Fr) Pers. (Aphyllophoromycetideae)
TLDR
Data suggest that daily oral administration of aqueous extract of H. erinaceus fresh fruiting bodies could promote the regeneration of injured rat peroneal nerve in the early stage of recovery.
Functional recovery enhancement following injury to rodent peroneal nerve by Lion's mane mushroom, Hericium erinaceus (Bull.: Fr.) Pers. (Aphyllophoromycetideae).
TLDR
Results suggest that daily administration of aqueous extract of H. erinaceus fresh firuitbodies has a beneficial effect on the recovery of injured rat peroneal nerve in the early stages of regeneration.
Potential activity of aqueous extract of culinary-medicinal Lion's Mane mushroom, Hericium erinaceus (Bull.: Fr.) Pers. (Aphyllophoromycetideae) in accelerating wound healing in rats.
TLDR
Wounds dressed with HEFB significantly enhanced the acceleration of wound healing enclosure in rats and showed less scar width at wound enclosure and the healed wound contained fewer macrophages and more collagen with angiogenesis, compared to wounds dressed with sdH2O.
Effect of Culinary-Medicinal Lion's Mane Mushroom, Hericium erinaceus (Bull.: Fr.) Pers. (Aphyllophoromycetideae), on Ethanol-Induced Gastric Ulcers in Rats
TLDR
Overall, rats pretreated with only distilled water suffered extensive hemorrhagic gastric mucosa lesions, whereas pretreatment with H. erinaceus or omeprazole reduced ulceration, with better cytoprotection observed in ratspretreated with omepazole.
The influence of Hericium erinaceus extract on myelination process in vitro.
Myelin sheaths, wrapping axons, perform the following important functions: support, protection, feeding and isolation. Injury of myelin compact structure leads to an impairment and severe illness of
Lignosus rhinocerus (Cooke) Ryvarden: A Medicinal Mushroom That Stimulates Neurite Outgrowth in PC-12 Cells
TLDR
This is the first report on neurite-stimulating activities of L. rhinocerus as well as aqueous sclerotium extract, which contained neuroactive compounds that stimulated neurite outgrowth in vitro.
Nerve growth factor-inducing activity of Hericium erinaceus in 1321N1 human astrocytoma cells.
TLDR
H. erinaceus contains active compounds that stimulate NGF synthesis via activation of the JNK pathway; these compounds are not hericenones.
ERINACINE D, A STIMULATOR OF NGF-SYNTHESIS, FROM THE MYCELIA OF HERICIUM ERINACEUM
A novel diterpenoid, erinacine D, was isolated from the cultured mycelia of Hericium erinaceum. The structure of the compound was determined by interpretation of the spectral data and chemical
Effects of Hericium erinaceus on amyloid β(25-35) peptide-induced learning and memory deficits in mice.
TLDR
The mushroom Hericium erinaceus prevented impairments of spatial short-term and visual recognition memory induced by amyloid β(25-35) peptide, indicating that H. erinACEus may be useful in the prevention of cognitive dysfunction.
Antimutagenicity of extracts of Hericium erinaceus.
TLDR
Both water and ethanol extracts of the mycelium and fruiting body of Hericium erinaceus were examined by the Ames test using Salmonella typhimurium TA98 to screen for antimutagenic effects against 5 mutagens: AFB1, B[a]P, Glu-p-1, NQNO, and Trp-P-1.
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