Neuropsychopharmacological mechanisms of stimulant drug action in attention-deficit hyperactivity disorder: a review and integration

  title={Neuropsychopharmacological mechanisms of stimulant drug action in attention-deficit hyperactivity disorder: a review and integration},
  author={Mary V. Solanto},
  journal={Behavioural Brain Research},
  • M. Solanto
  • Published 1 July 1998
  • Psychology, Biology
  • Behavioural Brain Research

Experimental Strategies for Investigating Psychostimulant Drug Actions and Prefrontal Cortical Function in ADHD and Related Attention Disorders

Combinations of these approaches can be used in adolescent, adult, and aged animals to identify the parameters of cell and neural circuit function that are regulated by MPH and to establish an overarching explanation of how MPH impacts PFC operations from cellular through behavioral functional domains.

Understanding the Effects of Stimulant Medications on Cognition in Individuals with Attention-Deficit Hyperactivity Disorder: A Decade of Progress

This work reviews the objectively measured cognitive effects that accompany the subjectively assessed clinical responses to stimulant medications and offers interpretations of the progress made over the past decade in understanding the cognitive effects of stimulant medication on individuals with ADHD.

maging the Effects of Methylphenidate on Brain opamine: New Model on Its Therapeutic Actions for ttention-Deficit/Hyperactivity Disorder

The postulate that the MP’s therapeutic effects are due in part to its bility to enhance the magnitude of DA increases induced by stimuli that by themselves generate weak responses, enhancing their aliency and the attention and interest they elicit.



Effects of Acute Stimulant Medication on Cerebral Metabolism in Adults with Hyperactivity

The effects of an acute dose of stimulant medication on cerebral metabolism in adults with ADHD was examined using positron emission tomography with flurodeoxyglucose-18 as the tracer to produce a differential pattern of increases and decreases in regional metabolism throughout the regions of interest.

Effects of methylphenidate and behavioral contingencies on sustained attention in attention-deficit hyperactivity disorder: a test of the reward dysfunction hypothesis.

The results indicate that MPH improved sustained attention on a laboratory task (and reduced task-irrelevant and other disinhibited behaviors), whereas behavioral contingencies did not, and suggest that, although both interventions improved stimulus discrimination processes, only MPH enhanced processes that mediate the regulation of effort over time.

The action of stimulant medication in attention deficit disorder with hyperactivity: dopaminergic, noradrenergic, or both?

  • F. LevyG. Hobbes
  • Psychology
    Journal of the American Academy of Child and Adolescent Psychiatry
  • 1988
Methylphenidate was shown to diminish attention deficits in the hyperactive group, but when methylphenidate is preceded by haloperidol, this effect was blocked on all the vigilance subtests, suggesting that this action is a primarily dopaminergic action.

A dose-response and time-action analysis of autonomic and behavioral effects of methylphenidate in attention deficit disorder with hyperactivity.

It is suggested that attentional deficit and inadequate motor inhibition represent divergent behavioral manifestations of hyperactivity, possibly corresponding to divergent neurophysiological substrates.

Cerebral glucose metabolism in adults with attention deficit hyperactivity disorder after chronic stimulant treatment.

The behavioral data strongly indicate that methylphenidate and d-amphetamine are effective agents for the treatment of adults with ADHD, as evidenced by improved ratings for restlessness and ability to maintain attention.

Catecholamines in attention-deficit hyperactivity disorder: current perspectives.

A multistage hypothesis is presented which emphasizes the interaction of norepinephrine, epinephrine, and dopamine in modulation of attention and impulse control.

Differential effects of methylphenidate on working memory in ADHD children with and without comorbid anxiety.

The presence of comorbid anxiety in children with ADHD predicts a less robust response to stimulant treatment and suggests that ADHD with anxiety may constitute a distinct and clinically meaningful subtype of ADHD.