Neuropsychological sequelae and impaired health status in survivors of severe acute respiratory distress syndrome.

  title={Neuropsychological sequelae and impaired health status in survivors of severe acute respiratory distress syndrome.},
  author={R O Hopkins and Lindell K. Weaver and Donna Pope and James F. Orme and E D Bigler and V Larson-Lohr},
  journal={American journal of respiratory and critical care medicine},
  volume={160 1},
Acute respiratory distress syndrome (ARDS) is a disease of acute respiratory failure manifested by severe hypoxemia with a high mortality rate. Previous outcome studies of ARDS have assessed survival and/or pulmonary function as the primary outcome variables. Cognitive or psychological outcomes following ARDS have not been described, despite the possibility that ARDS patients are at risk for brain injury through hypoxemia or other mechanisms. In the current study 55 consecutive ARDS survivors… 

Figures and Tables from this paper

Quality of life, emotional, and cognitive function following acute respiratory distress syndrome

Depression, anxiety, and intensive care unit length of stay were significantly correlated with decreased quality of life in ARDS survivors at 1-year post-hospital discharge, but cognitive impairments did not correlate with decreasedquality of life.

Neuromuscular and Neuropsychological Assessments in Survivors of Acute Respiratory Distress Syndrome: Exploratory Comparisons with an At-Risk Cohort

In this single-center population-based cohort study, survivors of ARDS in the community had similar reported functional impairment and depression prevalence compared to an at-risk cohort that did not develop ARDS.

Recovery and outcomes after the acute respiratory distress syndrome (ARDS) in patients and their family caregivers

Research is needed in family members of ARDS survivors to better understand long-term outcomes of the post-ICU family syndrome and to evaluate how it affects patient recovery.

The adult respiratory distress syndrome cognitive outcomes study: long-term neuropsychological function in survivors of acute lung injury.

Neuropsychological function can be assessed by telephone in a multicenter trial and Hypoxemia is a risk factor for long-term neuropsychological impairment, which is common in survivors of ALI.

Two-year cognitive, emotional, and quality-of-life outcomes in acute respiratory distress syndrome.

The ARDS survivors had decreased quality of life, with the physical domains improving at 1 year, with no additional change at 2 years, and role emotional, pain, and general health did not change from hospital discharge to 2 years.

Long-term cognitive impairment after acute respiratory distress syndrome: a review of clinical impact and pathophysiological mechanisms

Interventions such as minimizing mechanical ventilation tidal volume, minimizing duration of exposure to sedating medications, maintaining hemodynamic stability, optimizing fluid balance, and implementing bundles to enhance patient care help dramatically to reduce duration of delirium and may help prevent acquisition of long-term cognitive impairment.

Long-term cognitive impairment after critical illness.

A longer duration of delirium in the hospital was associated with worse global cognition and executive function scores at 3 and 12 months, and use of sedative or analgesic medications was not consistently associated with cognitive impairment at 3 or 12 months.

Prominent Cognitive Impairment Sequelae in Adult Survivors of Acute Respiratory Distress Syndrome

Survivors of an intensive care unit stay for ARDS often develop cognitive impairment persisting long after their admission, and Clinicians in rehabilitation facilities should screen for these sequelae and connect survivors with treatment to improve cognitive outcomes.

Posttraumatic stress disorder in survivors of acute respiratory distress syndrome (ARDS) and septic shock

From a clinical point of view prophylactic stress doses of hydrocortisone may reduce the major risk of PTSD associated with ALI / ARDS.



Recovery of function in survivors of the acute respiratory distress syndrome.

Pulmonary function and self-perceived health scores improved considerably in the first 3 mo after extubation, with only slight additional improvement at 6 mo, but no further changes were evident at 1 yr.

Clinical Determinants of Abnormalities in Pulmonary Functions in Survivors of the Adult Respiratory Distress Syndrome

Long-term abnormalities of pulmonary function of survivors of ARDS were not related to initial lung impairment but were directly related to persistence of impaired lung function during the acute episode.

Causes of Mortality in Patients with the Adult Respiratory Distress Syndrome

It is indicated that sepsis syndrome, rather than respiratory failure, is the leading cause of death in patients with ARDS.

The adult respiratory distress syndrome. A report of survival and modifying factors.

Survival in ARDS patients is different from previous reports, the cause of death in patients isDifferent from that reported by Montgomery et al in 1985, and multisystem organ failure, sepsis, age, and some predisposing factors of ARDS continue to be associated with decreased survival.

Neuropsychologic findings in hypoxemic chronic obstructive pulmonary disease.

It is concluded that cerebral disturbance is common in hypoxemic COPD and may be related in part to decreased availability of oxygen to the brain.

Psychologic effects of continuous and nocturnal oxygen therapy in hypoxemic chronic obstructive pulmonary disease.

It is concluded that prolonged oxygen treatment is associated with small but definite improvement in brain functioning among patients with hypoxemic COPD, and that COT might have some advantage over NOT in enhancing neuropsychologic functioning as well as survival.

[Critical illness polyneuropathy: clinical aspects and long-term outcome].

The clinical outcome was markedly influenced by long-lasting neuropsychological disturbances in three of theFive patients with flaccid tetra- or paraparesis as well as by other complications such as joint contractures.

Improved survival of patients with acute respiratory distress syndrome (ARDS): 1983-1993.

A significant decrease in fatality rates is observed largely in patients younger than 60 years and in those with sepsis syndrome as their risk for ARDS, which should be considered in clinical trials designed to prevent ARDS and the high mortality associated with this syndrome.

Obstructive sleep apnea syndrome: pathogenesis of neuropsychological deficits.

Reductions in general intellectual measures, as well as in executive and psychomotor tasks were all attributable to the severity of hypoxemia, while other attention and memory deficits were related to vigiance impairment.

The adult respiratory distress syndrome. Clinical features, factors influencing prognosis and principles of management.

The adult respiratory distress syndrome (ARDS) is an important and common medical emergency and is likely to occur in all hospitals dealing in respiratory care. The syndrome occurs from a variety of