Neuropsychological function and symptoms in subjects with subclinical hypothyroidism and the effect of thyroxine treatment.

@article{Jorde2006NeuropsychologicalFA,
  title={Neuropsychological function and symptoms in subjects with subclinical hypothyroidism and the effect of thyroxine treatment.},
  author={Rolf Jorde and Knut Waterloo and Hilde M. Storhaug and Audhild Nyrnes and Johan A. Sundsfjord and Trond Jenssen},
  journal={The Journal of clinical endocrinology and metabolism},
  year={2006},
  volume={91 1},
  pages={
          145-53
        }
}
OBJECTIVE Our objective was to examine the relation between neuropsychological function and subclinical hypothyroidism (SHT), defined as serum TSH of 3.5-10.0 mIU/liter and normal serum free T4 and free T3 levels, and to study the effect of T4 supplementation. SUBJECTS A total of 89 subjects (45 males) with SHT and 154 control subjects (72 males) were recruited from a general health survey (the fifth Tromsø study). Sixty-nine of those with SHT were included in a placebo-controlled, double… Expand
The Effect of L-Thyroxine Treatment on Hypothyroid Symptom Scores and Lipid Profile in Children with Subclinical Hypothyroidism
TLDR
The results of this study showed that in children with SH the hypothyroidism symptom score was significantly higher than in euthyroid children, L-thyroxine treatment improved the Hypothyroidistan symptom score and SH does not seem to be associated with dyslipidemia. Expand
Low mood and response to Levothyroxine treatment in Indian patients with subclinical hypothyroidism.
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The administration of Levothyroxine therapy is associated with significant improvement in Hamilton Depression Rating Scale scores and there is a positive correlation between serum TSH levels and HAM-D scores, which underlines the importance of thyroid screening in cases of low mood. Expand
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TLDR
No neuropsychological change was found in patients with SH when compared with euthyroid individuals, and the results of the neurocognitive evaluation of 65 SH patients and 31 individuals without thyroid disease were similar. Expand
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TLDR
There were independent decrements in working memory, which suggests that subclinical hypothyroidism specifically impacts brain areas responsible for working memory. Expand
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Thyroid hypofunction is a slowly progressing graded phenomenon [Vanderpump MP, Tunbridge WM, French JM, Appleton D, Bates D, Clark F, et al. The incidence of thyroid disorders in the community: aExpand
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OBJECTIVES To evaluate the impact of subclinical hypothyroidism (sHT) treatment on health-related quality of life (QoL), psychiatric symptoms, clinical score, and muscle function. MATERIALS ANDExpand
Health status, psychological symptoms, mood, and cognition in L-thyroxine-treated hypothyroid subjects.
TLDR
This group of L-T4-treated subjects had decrements in health status, psychological function, working memory, and motor learning compared to euthyroid controls, and randomized studies targeting different TSH levels and memory subdomains would clarify these issues. Expand
Treated hypothyroidism, cognitive function, and depressed mood in old age: the Rancho Bernardo Study.
TLDR
Long-term treated hypothyroidism is not associated with impaired CF or depressed mood in old age, and the lack of association with CF is reassuring with regard to long-term use of thyroid hormone therapy. Expand
Cognitive function in subclinical and overt hypothyroidism
Introduction: Neurocognitive deficits in overt hypothyroidism are well documented. But there is a controversy as to if subclinical hypothyroidism is associated with impaired cognition. Our aim was toExpand
Depressive symptoms in patients with subclinical hypothyroidism – the effect of treatment with levothyroxine: a double-blind randomized clinical trial*
TLDR
The efficacy of treatment of subclinical hypothyroidism in people with levothyroxine in relation to depressive symptoms was showed and the affective subscale of Beck Depression Inventory did not change after 12 weeks of treatment with lev Timothyroxine, while somatic subscale remarkably improved in the intervention group. Expand
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