Neuropsychological assessment of hepatic encephalopathy: ISHEN practice guidelines

@article{Randolph2009NeuropsychologicalAO,
  title={Neuropsychological assessment of hepatic encephalopathy: ISHEN practice guidelines},
  author={Christopher Randolph and Robin C. Hilsabeck and Ainobu Kato and Parampreet Singh Kharbanda and Yu-yuan Li and Daniela Mapelli and L D Ravdin and Manuel Romero-G{\'o}mez and Andrea Stracciari and Karin Weissenborn},
  journal={Liver International},
  year={2009},
  volume={29}
}
Low‐grade or minimal hepatic encephalopathy (MHE) is characterised by relatively mild neurocognitive impairments, and occurs in a substantial percentage of patients with liver disease. The presence of MHE is associated with a significant compromise of quality of life, is predictive of the onset of overt hepatic encephalopathy and is associated with a poorer prognosis for outcome. Early identification and treatment of MHE can improve quality of life and may prevent the onset of overt… Expand
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  • L. Stinton, S. Jayakumar
  • Medicine
  • Canadian journal of gastroenterology = Journal canadien de gastroenterologie
  • 2013
TLDR
The diagnosis of MHE has traditionally been achieved through neuropsychological examination, psychometric tests or the newer critical flicker frequency test, and a new smartphone application (EncephalApp Stroop Test) may serve to function as a screening tool for patients requiring further testing. Expand
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TLDR
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TLDR
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TLDR
Treatment for MHE improves neuropsychiatric performance and quality of life and decreases the risk of developing overt HE (OHE).The agents used to treat OHE have been tested in patients with MHE and have all been shown to be beneficial, with documented improvement in psychometric performance after treatment. Expand
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TLDR
A highly sensible and specific non-invasive method of diagnosis is Magnetic Resonance Spectroscopy (MRS) which identifies the key neuro-biochemical profile of hepatic encephalopathy. Expand
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TLDR
An updated review on epidemiology, burden and quality of life, neuropsychological testing, neuroimaging, neurophysiology and therapy in subjects with MHE is performed. Expand
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TLDR
The controversy regarding the use of a categorical or a continuous approach in measuring the severity of HE is discussed and the new methods presented are also valuable for investigating the neurological manifestations occurring after liver transplantation. Expand
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TLDR
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Diagnosis of minimal hepatic encephalopathy.
  • K. Weissenborn
  • Medicine
  • Journal of clinical and experimental hepatology
  • 2015
TLDR
The currently most frequently used methods-EEG, critical flicker frequency, Continuous Reaction time Test, Inhibitory Control Test, computerized test batteries such as the Cognitive Drug Research test battery, the psychometric hepatic encephalopathy score (PHES) and the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS)-and their pros and cons are described. Expand
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