Neuropsychological and biochemical investigations in heterozygotes for phenylketonuria during ingestion of high dose aspartame (a sweetener containing phenylalanine)

@article{Trefz1994NeuropsychologicalAB,
  title={Neuropsychological and biochemical investigations in heterozygotes for phenylketonuria during ingestion of high dose aspartame (a sweetener containing phenylalanine)},
  author={F. Trefz and L. Sonneville and P. Matthis and C. Benninger and B. Lanz-Englert and H. Bickel},
  journal={Human Genetics},
  year={1994},
  volume={93},
  pages={369-374}
}
  • F. Trefz, L. Sonneville, +3 authors H. Bickel
  • Published 1994
  • Biology, Medicine
  • Human Genetics
  • Aspartame, a high intensity sweetener, is used extensively worldwide in over 5,000 products. Upon ingestion, aspartame is completely metabolized to two amino acids and methanol (approximately 50% phenylalanine, 40% aspartic acid, and 10% methanol). The effects of aspartame on cognitive function, electroencephalograms (EEGs) and biochemical parameters were evaluated in 48 adult (21 men, 27 women) heterozygotes for phenylketonuria (PKUH). PKUH subjects whose carrier status had been proven by DNA… CONTINUE READING

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