Neuropsychological Consequences of Opiate Use

  title={Neuropsychological Consequences of Opiate Use},
  author={Staci A. Gruber and Marisa M. Silveri and Deborah A. Yurgelun-Todd},
  journal={Neuropsychology Review},
Approximately 3.7 million individuals have used heroin and other opiate substances in their lifetime. Despite increasing knowledge of the effects of heroin, it remains the most abused opiate and use among adults has recently increased. The empirical literature examining the neurocognitive effects of acute and chronic opioid use remains limited; however, findings to date suggest that the use of opiates has both acute and long-term effects on cognitive performance. Neuropsychological data… 

Cognitive Functioning in Methadone Use

9 Cognitive Impairments in Drug Addicts

Putative aging effects including inhibition of neurogenesis and enhanced apoptosis underline the dark side of drug addiction and will doubtlessy be a challenge for future research.

Cognitive Impairments in Drug Addicts

Putative aging effects including inhibition of neurogenesis and enhanced apoptosis underline the dark side of drug addiction and will doubtlessy be a challenge for future research.

Impulsivity and opioid drugs: differential effects of heroin, methadone and prescribed analgesic medication

Data support the hypothesis that different aspects of neuropsychological measures of impulsivity appear to be associated with exposure to different opioids, and identify impairments that may represent an underlying trait vulnerability to opioid dependence.

Executive functioning in addicts following health mobile cognitive stimulation Evidence from alcohol and heroin patients

  • P. GamitoJorge Oliveira A. Deus
  • Psychology, Medicine
    2013 7th International Conference on Pervasive Computing Technologies for Healthcare and Workshops
  • 2013
Overall increase of general cognitive abilities and executive functioning following cognitive stimulation, being more pronounced in alcoholics who were assigned to treatment group with mobile technologies in comparison to paper-and-pencil group and controls are shown.

Neuropsychological consequences of alcohol and drug abuse on different components of executive functions

Findings indicate that alcohol abuse is negatively associated with fluency and decision-making deficits, whereas the different drugs motivating treatment have both generalized and specific deleterious effects on different executive components.

Impulsivity, cognitive function, and their relationship in heroin-dependent individuals

Self-reported impulsivity was uncorrelated with cognitive function and underlying brain-related factors in heroin dependence are suggested and have implications for therapeutic intervention.

Cognitive effects of labeled addictolytic medications




Neuropsychological functioning in opiate addicts.

Performance on neuropsychological tests was shown to be independent of current or past levels of opiate use and to be of little prognostic significance in relation to treatment outcome, but a comparatively strong association was noted between measures of neuroPsychological functioning and educational achievement.

Methadone maintenance improves cognitive performance after two months of treatment.

Results suggest that opiate-dependent subjects exhibit significant improvement in cognitive function after MM treatment, and no effect of illicit drug use was observed when the sample was stratified by urine toxicology results.

Neuropsychological deficits and opiate abuse.

Neuropsychological performance in opiate addicts after rapid detoxification.

Effects of methadone on cognition, mood and craving in detoxifying opiate addicts: a dose-response study

A single dose of methadone can induce episodic memory impairment in patients who have a history of heroin use averaging more than 10 years and such impairment can be avoided by giving methamphetamineadone in divided doses.

Intellectual and neuropsychological functions in young men with heavy and long-term patterns of drug abuse.

Intellectual and neuropsychological tests sensitive to brain dysfunction revealed no intergroup differences, and this finding casts some doubt on other reports suggesting that long-term drug abuse results in neuro psychological disorders.

Opioid abuse and cognitive performance.

Cognitive impairment in methadone maintenance patients.

Cerebral metabolism in opiate-dependent subjects: effects of methadone maintenance.

The results of this study suggest that neurobiological abnormalities can persist in the brain of a chronic opiate user several years after detoxification from methadone.