Neuropsychiatric symptoms in Parkinson's disease: fronto-striatal atrophy contributions.

  title={Neuropsychiatric symptoms in Parkinson's disease: fronto-striatal atrophy contributions.},
  author={Claire O'Callaghan and James M. Shine and Simon J G Lewis and Michael Hornberger},
  journal={Parkinsonism & related disorders},
  volume={20 8},
BACKGROUND Neuropsychiatric symptoms (NPS) in Parkinson's disease (PD) have been mostly attributed to neurotransmitter imbalances. However, recent findings suggest that gray matter atrophy also contributes to NPS in PD. We contrast PD patients with different levels of NPS, who are well-matched for dopaminergic medication levels and disease stage, to identify the fronto-striatal gray matter atrophy areas associated with NPS in PD. METHODS Fifty mild, non-demented PD patients were included. We… CONTINUE READING
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