Neuropsychiatric side-effects of interferon-alpha treatment: pathophysiology and therapeutic options.

@article{Zahiu2014NeuropsychiatricSO,
  title={Neuropsychiatric side-effects of interferon-alpha treatment: pathophysiology and therapeutic options.},
  author={Carmen Mihaela Denise Zahiu and Mihai Rimbaş},
  journal={Maedica},
  year={2014},
  volume={9 2},
  pages={121-6}
}
Interferon alpha (IFN-α) is the approved standard of care for chronic hepatitis C and B. Unfortunately, it has neuropsychiatric side-effects that have a major impact upon the quality of life and the drug adherence. The mechanism of IFN-α-induced behavioral changes is complex, involving interactions between the immune system, the endocrine system, the monoaminergic systems and the opioid receptors. Recent studies support the neurodegeneration hypothesis as a possible mechanism of IFN-α-induced… CONTINUE READING