Neuropsychiatric manifestations of Sydenham's chorea: a systematic review

@article{Punukollu2016NeuropsychiatricMO,
  title={Neuropsychiatric manifestations of Sydenham's chorea: a systematic review},
  author={Mallika Punukollu and Nadine Mushet and Marisa Linney and Colm Hennessy and Michael J. S. Morton},
  journal={Developmental Medicine \& Child Neurology},
  year={2016},
  volume={58}
}
Sydenham's chorea is a post‐streptococcal, autoimmune, neuropsychiatric movement disorder. Sydenham's chorea is a major criterion for diagnosis of acute rheumatic fever with the implication of potential long‐term sequelae including cardiac complications. It is well established that there is psychiatric comorbidity in Sydenham's chorea, but there are variations in the literature regarding the nature and prevalence of psychiatric diagnoses associated with Sydenham's chorea. The aim of this review… 
Sydenham’s chorea: from pathophysiology to therapeutics
TLDR
The authors review the pathophysiology, clinical characteristics, and available evidence on therapeutic strategies, the latter including the secondary prevention of GABHS infections, reduction of chorea, and immune modulation.
A nationwide study on Sydenham's chorea: Clinical features, treatment and prognostic factors.
  • A. Orsini, T. Foiadelli, S. Savasta
  • Medicine, Psychology
    European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society
  • 2021
Sydenham's chorea: beyond involuntary movements
  • A. Teixeira
  • Medicine, Psychology
    Developmental medicine and child neurology
  • 2016
TLDR
Based on the analysis of qualitative (case reports) and comparison studies, children and adolescents with Sydenham’s chorea are at increased risk of neuropsychiatric symptoms and disorders, which are highly prevalent, notably OCD, attention-deficit–hyperactivity disorder (ADHD), and anxiety disorders.
Treatment of Sydenham’s Chorea: A Review of the Current Evidence
TLDR
It is found that chorea often improves with symptomatic therapy and immunotherapy tends to be reserved for those who fail to respond, and Steroids are beneficial; however, data using IVIG and plasmapheresis are very limited.
Neurologic complications of rheumatic fever.
Uncontrollable movements of right upper and lower extremities in a child: A diagnostic puzzle
TLDR
A case of a 9‐year‐old child who presented with uncontrollable, involuntary movements associated with a recent streptococcal infection and echocardiographic evidence of valvulitis is described, consistent with the diagnosis of Sydenham's chorea.
Acute Movement Disorders in Childhood
TLDR
Common and uncommon causes of acute-onset movement disorders are summarized, focusing on clinical presentation and appropriate diagnostic investigations, to provide a useful clinician’s guide to this expanding field of pediatric neurology.
PANDAS and PANS: Clinical, Neuropsychological, and Biological Characterization of a Monocentric Series of Patients and Proposal for a Diagnostic Protocol.
TLDR
Patients with PANS had a complex clinical presentation and a compromised neuropsychological profile with respect to patients with PANDAS or SC, and a pilot diagnostic protocol is proposed that will allow comparison with similar childhood-onset neuropsychiatric disorders, such as obsessive-compulsive or tic disorders, and efficacy evaluation of different therapeutic approaches.
...
...

References

SHOWING 1-10 OF 83 REFERENCES
The prevalence of neuropsychiatric disorders in Sydenham's chorea.
Sydenham's chorea and psychopathology.
TLDR
The total number of psychiatric symptoms 10 years after the initial contact was much greater in the study group than in controls (p less than 0.001), and schizophrenia was more common in theStudy group compared to controls.
An update on the treatment of Sydenham’s chorea: the evidence for established and evolving interventions
TLDR
Small studies have demonstrated trends to support the use of immunoglobulins and steroids as therapeutic interventions for children affected by Sydenham’s chorea.
Psychosis following acute Sydenham’s chorea
TLDR
A case of a 13-year-old boy with brief psychotic episode following acuteydenham's chorea is reported, providing further insight about the involvement of basal ganglia dysfunction on psychosis.
Sydenham's chorea-clinical characteristics of nine patients.
Distinguishing PANDAS from Sydenham's chorea: case report and review of the literature.
Sydenham's chorea.
  • F. Cardoso
  • Medicine, Psychology
    Handbook of clinical neurology
  • 2011
Septuagenarian Sydenham's with secondary hypomania.
  • K. Black, J. Perlmutter
  • Psychology, Medicine
    Neuropsychiatry, neuropsychology, and behavioral neurology
  • 1997
TLDR
This case is the first report of criteria-based secondary mania with probable Sydenham's chorea, as well as the longest reported remission between symptomatic SydenHAM's episodes, and supports current pathophysiologic theories of idiopathic mania.
Sydenham's chorea: Long-term immunosuppression for psychiatric symptoms
TLDR
Two adolescents with no prior neuropsychiatric disorders who developed SC and psychiatric symptomatology that did not respond to conventional psy- chiatric drugs are described, suggesting an underlying autoimmune disorder causing behavioral changes and offers a therapeutic option in neuroleptic resistant cases.
Sydenham's chorea: clinical observations from a Brazilian movement disorder clinic.
...
...