Neuropsychiatric disorders: Shared genetics of bipolar disorder and schizophrenia

@article{Potash2009NeuropsychiatricDS,
  title={Neuropsychiatric disorders: Shared genetics of bipolar disorder and schizophrenia},
  author={James B. Potash and O Joseph Bienvenu},
  journal={Nature Reviews Neurology},
  year={2009},
  volume={5},
  pages={299-300}
}
Bipolar disorder and schizophrenia share common clinical features, and antipsychotic medications can treat both conditions effectively. An assessment of 73,929 people with bipolar disorder and/or schizophrenia from a Swedish registry found evidence that the two disorders also share more than half of their genetic determinants. 
A dimensional approach to the psychosis spectrum between bipolar disorder and schizophrenia: The Schizo-Bipolar Scale
TLDR
The data suggest a hybrid conceptualization model with a representation of cases with prototypic schizophrenia or bipolar disorder at the extremes, but a large group of patients on the continuum between them that traditionally would be considered schizoaffective. Expand
Comparative Neuropsychiatry: White Matter Abnormalities in Children and Adolescents with Schizophrenia, Bipolar Affective Disorder, and Obsessive-Compulsive Disorder
TLDR
White matter abnormalities in early-onset schizophrenia and bipolar affective disorder are more global in nature, whereas children and adolescents with obsessive-compulsive disorder do not show widespread differences in FA. Expand
Prospective Memory Performance in Persons With Schizophrenia and Bipolar Disorder and Healthy Persons
TLDR
Patients were found to be impaired in PM relative to controls and the two patient groups showed similar level of PM performance after controlling confounding sociodemographic and clinical variables. Expand
Patients with bipolar disorders share similar but attenuated prospective memory impairments with patients with schizophrenia
TLDR
Patients with bipolar disorder shared a similar PM impairment with those with schizophrenia, extending the similarity in neurocognitive impairments between the two psychiatric disorders to PM. Expand
A genome-wide meta-analysis identifies novel loci associated with schizophrenia and bipolar disorder
TLDR
This study performed a meta-analysis for genome-wide association data of the Affymetrix Genome-Wide Human SNP array 6.0 to detect genetic variants influencing both schizophrenia and bipolar disorder using European-American samples, and found two additional associated genes NALCN and NAP5. Expand
Early Recognition of High Risk of Bipolar Disorder and Psychosis: An Overview of the ZInEP “Early Recognition” Study
TLDR
The rationale and design of a prospective longitudinal study focused on at-risk states of psychosis and bipolar disorder, carried out within the context of the Zurich Program for Sustainable Development of Mental Health services are provided. Expand
Does Antidepressant Treatment Improve Cognition in Older People with Schizophrenia or Schizoaffective Disorder and Comorbid Subsyndromal Depression?
TLDR
Although there are other cogent reasons why SSD in schizophrenia warrant direct intervention, treatment does not substantially affect the level of cognitive functioning and there remains an ongoing need to identify effective means of directly ameliorating them. Expand
Comparison of automatic visual attention in schizophrenia, bipolar disorder, and major depression: Evidence from P1 event‐related component
TLDR
The present study sought to compare the automatic visual attention mechanisms in three psychiatric disorders considered to distribute along the continuum of psychosis severity: schizophrenia (SCZ), bipolar disorder (BD), and major depressive disorder (MDD), and measured the visual P1 event‐related potential component. Expand
Exonic DNA Sequencing of ERBB4 in Bipolar Disorder
TLDR
The modest sample size in this study cannot definitively rule out a role for rare variants in bipolar disorder and studies with larger sample sizes are needed to confirm the observed association, but did uncover a modestly associated novel variant that could affect alternative splicing of ERBB4. Expand
Disrupted action monitoring in recent-onset psychosis patients with schizophrenia and bipolar disorder
TLDR
Altered error- and conflict-monitoring occur together in the first-episode schizophrenia patients, and these measures are comparable in patients with the first day of psychosis onset, and the effects of antipsychotic medication may be related to these measures. Expand
...
1
2
3
4
...

References

SHOWING 1-10 OF 12 REFERENCES
Common genetic determinants of schizophrenia and bipolar disorder in Swedish families: a population-based study
TLDR
Evidence is shown that schizophrenia and bipolar disorder partly share a common genetic cause, which is consistent with a reappraisal of these disorders as distinct diagnostic entities. Expand
DISC1 association, heterogeneity and interplay in schizophrenia and bipolar disorder
TLDR
These findings provide further support for the role of DISC1 in psychiatric illness and demonstrate the presence of locus heterogeneity, with the effect that clinically relevant genetic variants may go undetected by standard analysis of combined cohorts. Expand
The genetic deconstruction of psychosis.
TLDR
Understanding of the brain mechanisms that link specific gene actions and products to the subjective experience of psychopathological symptoms is likely to be bridged by employing intermediate (or endo-) phenotypes in the domains such as cognition, neurophysiology, or neuroanatomy rather than relying upon clinical measures alone. Expand
Carving Chaos: Genetics and the Classification of Mood and Psychotic Syndromes
  • J. Potash
  • Psychology, Medicine
  • Harvard review of psychiatry
  • 2006
TLDR
Evidence from the fields of genetic epidemiology, linkage, association, cytogenetics, and gene expression suggests some overlap in the genes that predispose to bipolar disorder and schizophrenia. Expand
Operation of the schizophrenia susceptibility gene, neuregulin 1, across traditional diagnostic boundaries to increase risk for bipolar disorder.
TLDR
The findings suggest that neuregulin 1 plays a role in influencing susceptibility to bipolar disorder and schizophrenia and that it may exert a specific effect in the subset of functional psychosis that has manic and mood-incongruent psychotic features. Expand
Suggestive linkage to chromosomal regions 13q31 and 22q12 in families with psychotic bipolar disorder.
TLDR
Bipolar disorder families in which psychotic symptoms cluster may carry susceptibility genes on chromosomal regions 13q31 and 22q12, and these overlapping phenotypes may correlate most closely with the putative susceptibility genes. Expand
Neuregulin 1 and susceptibility to schizophrenia.
TLDR
The results of a genomewide scan of schizophrenia families in Iceland show that schizophrenia maps to chromosome 8p, and extensive fine-mapping of the 8p locus and haplotype-association analysis identifies neuregulin 1 (NRG1) as a candidate gene for schizophrenia. Expand
Schizophrenia susceptibility loci on chromosomes 13q32 and 8p21
TLDR
A genome-wide scan for schizophrenia susceptibility loci (SSL) using 452 microsatellite markers on 54 multiplex pedigrees is presented and it is more probable that chromosome 8 may be a false positive linkage. Expand
Evidence for associations between PDE4D polymorphisms and a subtype of neuroticism
TLDR
The effects of PDE4D on personality traits related to neuroticism in healthy subjects as well as in patients with major depression were sought, and nominal associations for 38 SNPs with NEU, HA and HA subscales were found, suggesting a genotypic and allelic model of inheritance. Expand
Rethinking psychosis: the disadvantages of a dichotomous classification now outweigh the advantages.
  • N. Craddock, M. Owen
  • Medicine
  • World psychiatry : official journal of the World Psychiatric Association
  • 2007
TLDR
If psychiatry is to translate the opportunities offered by new research methodologies, it must move to a classificatory approach that is worthy of the 21st century, both immediately and for DSM-V and ICD-11. Expand
...
1
2
...