Neuropsychiatric changes precede classic motor symptoms in ALS and do not affect survival.

  title={Neuropsychiatric changes precede classic motor symptoms in ALS and do not affect survival.},
  author={Eneida Mioshi and J Caga and Patricia Lillo and Sharpley Hsieh and Eleanor Ramsey and Emma M Devenney and Michael Hornberger and John R. Hodges and Matthew C Kiernan},
  volume={82 2},
OBJECTIVES To investigate patient susceptibility to neuropsychiatric symptoms in the context of progression of more classic motor symptoms in amyotrophic lateral sclerosis (ALS) and to examine the impact of neuropsychiatric symptoms on survival. METHODS The study cohort consisted of 219 patients with ALS (limb onset = 159; bulbar onset = 60), with neuropsychiatric symptoms measured using the Motor Neuron Disease Behavioural Scale and more classic ALS symptoms assessed by the Amyotrophic… CONTINUE READING
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