Neuroprotective strategies for basal ganglia degeneration: Parkinson’s and Huntington’s diseases

@article{Alexi2000NeuroprotectiveSF,
  title={Neuroprotective strategies for basal ganglia degeneration: Parkinson’s and Huntington’s diseases},
  author={Tajrena Alexi and Cesario V. Borlongan and Richard L. M. Faull and Chris E. Williams and Paul E. Hughes},
  journal={Progress in Neurobiology},
  year={2000},
  volume={60},
  pages={409-470}
}
There are three main mechanisms of neuronal cell death which may act separately or cooperatively to cause neurodegeneration. This lethal triplet of metabolic compromise, excitotoxicity, and oxidative stress causes neuronal cell death that is both necrotic and apoptotic in nature. Aspects of each of these three mechanisms are believed to play a role in the neurodegeneration that occurs in both Parkinson's and Huntington's diseases. Strategies to rescue or protect injured neurons usually involve… CONTINUE READING

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