Neuroprotective role of MMP-9 overexpression in the brain of Alzheimer's 5xFAD mice.

@article{Fragkouli2014NeuroprotectiveRO,
  title={Neuroprotective role of MMP-9 overexpression in the brain of Alzheimer's 5xFAD mice.},
  author={Apostolia Fragkouli and Effie C. Tsilibary and Athina K. Tzinia},
  journal={Neurobiology of disease},
  year={2014},
  volume={70},
  pages={179-89}
}
Accumulation of amyloid-β (Αβ) peptide is believed to play a central role in the pathogenesis of Alzheimer's disease (AD). Lowering Aβ levels in the brain may thus improve synaptic and cognitive deficits observed in AD patients. In the non-amyloidogenic pathway, the amyloid-β precursor protein (APP) is cleaved within the Aβ peptide sequence by α-secretases, giving rise to the potent neurotrophic N-terminal fragment sΑPPα. We have previously reported that gelatinase B/matrix metalloproteinase 9… CONTINUE READING
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