Neuroprotective role of L-carnitine in the 3-nitropropionic acid induced neurotoxicity.

  title={Neuroprotective role of L-carnitine in the 3-nitropropionic acid induced neurotoxicity.},
  author={Zbigniew K. Binienda and S. Fatehyab Ali},
  journal={Toxicology letters},
  volume={125 1-3},
L-carnitine (LC) plays an important regulatory role in the mitochondrial transport of long-chain free fatty acids (FFA). 3-Nitropropionic acid (3-NPA) is known to induce cellular energy deficit and oxidative stress related neurotoxicity via an irreversible inhibition of the mitochondrial enzyme succinate dehydrogenase (SDH). Protective effects of L-carnitine on the neurotoxicity induced by 3-NPA have been shown in vitro. Here, the activities of SDH as well as the activity of the antioxidant… CONTINUE READING
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