Neuroprotective properties of prostaglandin I2 IP receptor in focal cerebral ischemia.

@article{Saleem2010NeuroprotectivePO,
  title={Neuroprotective properties of prostaglandin I2 IP receptor in focal cerebral ischemia.},
  author={Sofiyan Saleem and Zahoor Ahmad Shah and Takayuki Maruyama and Shuh Narumiya and Sylvain Dor{\'e}},
  journal={Neuroscience},
  year={2010},
  volume={170 1},
  pages={
          317-23
        }
}
We and others have identified that inhibition of cyclooxygenase might not be the optimal approach to limiting brain damage after stroke. Now we are investigating the unique properties of the various prostaglandin receptors to determine whether blocking those that mediate toxicity or stimulating those that reduce toxicity will improve neurological outcomes. Here, we determined the respective contribution of the prostaglandin I(2) (PGI(2)) receptor in transient middle cerebral artery (MCA… CONTINUE READING
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