Neuroprotective properties of nootropic dipeptide GVS-111 inin vitro oxygen-glucose deprivation, glutamate toxicity and oxidative stress

@article{Andreeva2007NeuroprotectivePO,
  title={Neuroprotective properties of nootropic dipeptide GVS-111 inin vitro oxygen-glucose deprivation, glutamate toxicity and oxidative stress},
  author={N. Andreeva and E. V. Stel’mashuk and N. Isaev and R. Ostrovskaya and T. Gudasheva and I. V. Viktorov},
  journal={Bulletin of Experimental Biology and Medicine},
  year={2007},
  volume={130},
  pages={969-972}
}
  • N. Andreeva, E. V. Stel’mashuk, +3 authors I. V. Viktorov
  • Published 2007
  • Chemistry
  • Bulletin of Experimental Biology and Medicine
    • Argon anoxia and glucose deprivation were used for modeling of ischemic damage in the cultures of cerebellar granule cells. Protective effect of peptide piracetam analogue GVS-111 was demonstrated. GVS-111 prevented neurodegeneration induced by glutamate and oxidative stress. In contrast to GVS-111, piracetam did not attenuate neurocytotoxic effect of glutamate. 
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    References

    SHOWING 1-8 OF 8 REFERENCES
    Memory restoring and neuroprotective effects of the proline-containing dipeptide, GVS-111, in a photochemical stroke model.
    • 28
    Phosphatase activity in the lymph during the febrile reaction
    • 3
    Inhibition of Na+/Ca2+ exchange enhances delayed neuronal death elicited by glutamate in cerebellar granule cell cultures
    • 122
    Neuropathobiology of Senile Dementia and Mechanism of Action of Nootropic Drugs
    • 17
    Effects of piracetam on single central neurons.
    • 9
    Nootropic Drugs Positively Modulate α‐Amino‐3‐Hydroxy‐5‐Methyl‐4‐Isoxazolepropionic Acid‐Sensitive Glutamate Receptors in Neuronal Cultures
    • 84
    Substituted Acyl-proline Glycine Gvs-111 Combines Cognition Enhancing And Neuroprotective Activities
    • 4
    Sieso, Cerebrovasc
    • Ibid., 109,
    • 1990