Neuroprotective properties of nootropic dipeptide GVS-111 inin vitro oxygen-glucose deprivation, glutamate toxicity and oxidative stress

@article{Andreeva2007NeuroprotectivePO,
  title={Neuroprotective properties of nootropic dipeptide GVS-111 inin vitro oxygen-glucose deprivation, glutamate toxicity and oxidative stress},
  author={N. Andreeva and E. V. Stel’mashuk and N. Isaev and R. Ostrovskaya and T. Gudasheva and I. V. Viktorov},
  journal={Bulletin of Experimental Biology and Medicine},
  year={2007},
  volume={130},
  pages={969-972}
}
  • N. Andreeva, E. V. Stel’mashuk, +3 authors I. V. Viktorov
  • Published 2007
  • Chemistry
  • Bulletin of Experimental Biology and Medicine
  • Argon anoxia and glucose deprivation were used for modeling of ischemic damage in the cultures of cerebellar granule cells. Protective effect of peptide piracetam analogue GVS-111 was demonstrated. GVS-111 prevented neurodegeneration induced by glutamate and oxidative stress. In contrast to GVS-111, piracetam did not attenuate neurocytotoxic effect of glutamate. 
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