Neuroprotective properties of memantine in different in vitro and in vivo models of excitotoxicity

@article{Volbracht2006NeuroprotectivePO,
  title={Neuroprotective properties of memantine in different in vitro and in vivo models of excitotoxicity},
  author={Christiane Volbracht and Johan van Beek and Changlian Zhu and Klas Blomgren and Marcel Leist},
  journal={European Journal of Neuroscience},
  year={2006},
  volume={23}
}
The pathogenesis of stroke, trauma and chronic degenerative diseases, such as Alzheimer's disease (AD), has been linked to excitotoxic processes due to inappropriate stimulation of the N-methyl-D-aspartate receptor (NMDA-R. [...] Key Method We explored in a series of models of increasing complexity, whether this voltage-dependent channel blocker had neuroprotective properties at clinically relevant concentrations. As expected, memantine protected neurons in organotypic hippocampal slices or dissociated…Expand
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