Neuroprotective peptides fused to arginine-rich cell penetrating peptides: Neuroprotective mechanism likely mediated by peptide endocytic properties.

@article{Meloni2015NeuroprotectivePF,
  title={Neuroprotective peptides fused to arginine-rich cell penetrating peptides: Neuroprotective mechanism likely mediated by peptide endocytic properties.},
  author={Bruno P Meloni and Diego Milani and Adam B Edwards and Ryan S. Anderton and Ryan L. O'Hare Doig and Melinda Fitzgerald and Tim N. Palmer and Neville W. Knuckey},
  journal={Pharmacology & therapeutics},
  year={2015},
  volume={153},
  pages={
          36-54
        }
}
Several recent studies have demonstrated that TAT and other arginine-rich cell penetrating peptides (CPPs) have intrinsic neuroprotective properties in their own right. Examples, we have demonstrated that in addition to TAT, poly-arginine peptides (R8 to R18; containing 8-18 arginine residues) as well as some other arginine-rich peptides are neuroprotective in vitro (in neurons exposed to glutamic acid excitotoxicity and oxygen glucose deprivation) and in the case of R9 in vivo (after permanent… CONTINUE READING
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