Neuroprotective mechanisms of cerium oxide nanoparticles in a mouse hippocampal brain slice model of ischemia.

@article{Estevez2011NeuroprotectiveMO,
  title={Neuroprotective mechanisms of cerium oxide nanoparticles in a mouse hippocampal brain slice model of ischemia.},
  author={Ana Y. Estevez and Sonya Pritchard and Kelly Harper and Jeffrey William Aston and Adam E. Lynch and Jessica J. Lucky and J S Ludington and Prav Chatani and William P Mosenthal and James C Leiter and Silvana Andreescu and Joseph S. Erlichman},
  journal={Free radical biology & medicine},
  year={2011},
  volume={51 6},
  pages={1155-63}
}
Cerium oxide nanoparticles (nanoceria) are widely used as catalysts in industrial applications because of their potent free radical-scavenging properties. Given that free radicals play a prominent role in the pathology of many neurological diseases, we explored the use of nanoceria as a potential therapeutic agent for stroke. Using a mouse hippocampal brain slice model of cerebral ischemia, we show here that ceria nanoparticles reduce ischemic cell death by approximately 50%. The… CONTINUE READING