Neuroprotective mechanism of glial cell line-derived neurotrophic factor in mesencephalic neurons.

@article{Sawada2000NeuroprotectiveMO,
  title={Neuroprotective mechanism of glial cell line-derived neurotrophic factor in mesencephalic neurons.},
  author={Hideyuki Sawada and Masakazu Ibi and Takeshi Kihara and Makoto Urushitani and Miki Nakanishi and Akinori Akaike and Shun Shimohama},
  journal={Journal of neurochemistry},
  year={2000},
  volume={74 3},
  pages={1175-84}
}
Glial cell line-derived neurotrophic factor (GDNF) provides neuroprotection, but its neuroprotective mechanism has not been resolved. We investigated the neuroprotective mechanism of GDNF using primary culture of the rat mesencephalon. Bleomycin sulfate (BLM) and L-buthionine-[S,R]-sulfoximine (BSO) caused apoptosis in both dopaminergic and nondopaminergic neurons, as revealed by the presence of chromatin condensation, and positive staining by terminal deoxynucleotidyl transferase-mediated… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 25 extracted citations

Neurotrophic effects of serum- and glucocorticoid-inducible kinase on adult murine mesencephalic dopamine neurons.

The Journal of neuroscience : the official journal of the Society for Neuroscience • 2012
View 1 Excerpt

Similar Papers

Loading similar papers…