Neuroprotective function of human neuroglobin is correlated with its guanine nucleotide dissociation inhibitor activity.

@article{Watanabe2008NeuroprotectiveFO,
  title={Neuroprotective function of human neuroglobin is correlated with its guanine nucleotide dissociation inhibitor activity.},
  author={Seiji Watanabe and Keisuke Wakasugi},
  journal={Biochemical and biophysical research communications},
  year={2008},
  volume={369 2},
  pages={695-700}
}
Mammalian neuroglobin (Ngb) is involved in neuroprotection under oxidative stress conditions such as ischemia and reperfusion. However, the neuroprotective mechanism remains unclear. We previously demonstrated that human ferric Ngb binds to the alpha-subunits of heterotrimeric G proteins (Galpha(i/o)) and acts as a guanine nucleotide dissociation inhibitor (GDI) for Galpha(i/o). In the present study, we used a protein delivery reagent, Chariot, to investigate whether the GDI activity of human… CONTINUE READING

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