Neuroprotective efficacy of FR901459, a novel derivative of cyclosporin A, in in vitro mitochondrial damage and in vivo transient cerebral ischemia models.

@article{Muramatsu2007NeuroprotectiveEO,
  title={Neuroprotective efficacy of FR901459, a novel derivative of cyclosporin A, in in vitro mitochondrial damage and in vivo transient cerebral ischemia models.},
  author={Yuko Muramatsu and Yasuhisa Furuichi and Nobuteru Tojo and Akira Moriguchi and Takuya Maemoto and Hirohisa Nakada and Motohiro Hino and Nobuya Matsuoka},
  journal={Brain research},
  year={2007},
  volume={1149},
  pages={181-90}
}
The immunosuppressant cyclosporin A (CsA) has been shown to exert potent neuroprotective effects, possibly via the inhibition of calcineurin and mitochondrial permeability transition pore formation. Here, we investigated the neuroprotective profile of a novel derivative of CsA, FR901459, by evaluating its effects against in vitro mitochondrial damage and in vivo brain damage in transient global or focal cerebral ischemia models, in comparison with those of CsA. Efficacy of calcineurin… CONTINUE READING

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