Neuroprotective efficacy and therapeutic window of the high-affinity N-methyl-D-aspartate antagonist conantokin-G: in vitro (primary cerebellar neurons) and in vivo (rat model of transient focal brain ischemia) studies.

@article{Williams2000NeuroprotectiveEA,
  title={Neuroprotective efficacy and therapeutic window of the high-affinity N-methyl-D-aspartate antagonist conantokin-G: in vitro (primary cerebellar neurons) and in vivo (rat model of transient focal brain ischemia) studies.},
  author={Antony J. Williams and Jitendra R. Dave and James B Phillips and Yvonne H Lin and R. Tyler McCabe and Frank C. Tortella},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2000},
  volume={294 1},
  pages={378-86}
}
Conantokin-G (Con-G), a 17-amino-acid peptide derived from marine snails and a potent N-methyl-D-aspartate (NMDA) antagonist, was evaluated for its neuroprotective properties in vitro and in vivo. In primary cerebellar neurons, Con-G was shown to decrease excitotoxic calcium responses to NMDA and to exhibit differential neuroprotection potencies against… CONTINUE READING