Neuroprotective efficacy and therapeutic time window of peroxynitrite decomposition catalysts in focal cerebral ischemia in rats#

@article{Thiyagarajan2004NeuroprotectiveEA,
  title={Neuroprotective efficacy and therapeutic time window of peroxynitrite decomposition catalysts in focal cerebral ischemia in rats\#},
  author={M. Thiyagarajan and C. Kaul and S. S. Sharma},
  journal={British Journal of Pharmacology},
  year={2004},
  volume={142}
}
Free radicals have been implicated in cerebral ischemia reperfusion (IR) injury. Massive production of nitric oxide and superoxide results in continuous formation of peroxynitrite even several hours after IR insult. This can produce DNA strand nicks, hydroxylation and/or nitration of cytosolic components of neuron, leading to neuronal death. Peroxynitrite decomposition catalysts 5,10,15,20‐tetrakis(N‐methyl‐4′‐pyridyl)porphyrinato iron (III) (FeTMPyP) and 5,10,15,20‐tetrakis(4‐sulfonatophenyl… Expand
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