Neuroprotective effects of valproic acid against hemin toxicity: possible involvement of the down-regulation of heme oxygenase-1 by regulating ubiquitin-proteasomal pathway.

Abstract

During hemorrhagic stroke induced by intracerebral hemorrhage (ICH), brain injury occurs from the deleterious actions of hemoglobin byproducts; induction of heme oxygenase-1 (HO-1) also plays a critical role in the neurotoxicity in ICH. Valproic acid (VPA), which is a commonly used drug in the treatment of epilepsy, has been reported to have neuroprotective… (More)
DOI: 10.1016/j.neuint.2012.12.019

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@article{Kwon2013NeuroprotectiveEO, title={Neuroprotective effects of valproic acid against hemin toxicity: possible involvement of the down-regulation of heme oxygenase-1 by regulating ubiquitin-proteasomal pathway.}, author={Kyoung Ja Kwon and Jung Nam Kim and Min Kyeong Kim and Su Young Kim and Kyu Suk Cho and Se Jin Jeon and Hahn Young Kim and Jong Hoon Ryu and Sun-Young Han and Jae Hoon Cheong and Louis Joseph Ignarro and Seol Heui Han and Chan Young Shin}, journal={Neurochemistry international}, year={2013}, volume={62 3}, pages={240-50} }