Neuroprotective effects of thymosin beta4 in experimental models of excitotoxicity.

  title={Neuroprotective effects of thymosin beta4 in experimental models of excitotoxicity.},
  author={Patrizia Popoli and Rita Pepponi and Alberto Martire and Monica Armida and Antonella P{\'e}zzola and Mariangela Galluzzo and Maria Rosaria Domenici and Rosa Luisa Potenza and Maria Teresa Tebano and Cristiana Mollinari and Daniela Merlo and Enrico Garaci},
  journal={Annals of the New York Academy of Sciences},
The aim of this study was to evaluate the possible neuroprotective effects of thymosin beta(4) in different models of excitotoxicity. The application of thymosin beta(4) significantly attenuated glutamate-induced toxicity both in primary cultures of cortical neurons and in rat hippocampal slices. In in vivo experiments, the intracerebroventricular administration of thymosin beta(4) significantly reduced hippocampal neuronal loss induced by kainic acid. These results show that thymosin beta(4… CONTINUE READING