Neuroprotective effects of the free radical scavenger Edaravone (MCI-186) in mice permanent focal brain ischemia.

@article{Shichinohe2004NeuroprotectiveEO,
  title={Neuroprotective effects of the free radical scavenger Edaravone (MCI-186) in mice permanent focal brain ischemia.},
  author={Hideo Shichinohe and Satoshi Kuroda and Hiroshi Yasuda and Tatsuya Ishikawa and Masaru Iwai and Masatsugu Horiuchi and Yoshinobu K Iwasaki},
  journal={Brain research},
  year={2004},
  volume={1029 2},
  pages={200-6}
}
The present study was aimed to evaluate the effect of the free radical scavenger Edaravone on infarct volume due to permanent MCA occlusion in mice and, if so, to elucidate the mechanism of its neuroprotective effects. Male Balb/c mice were subjected to permanent middle cerebral artery occlusion and were treated with 3.0 mg/kg of Edaravone or vehicle 30 min before ischemia. Infarct volume was assessed by 2,3,5-triphenyltetrazolium chloride (TTC) method after 24 h. Furthermore, in situ detection… CONTINUE READING