Neuroprotective effects of tetrodotoxin as a Na+ channel modulator and glutamate release inhibitor in cultured rat cerebellar neurons and in gerbil global brain ischemia.

@article{Lysko1994NeuroprotectiveEO,
  title={Neuroprotective effects of tetrodotoxin as a Na+ channel modulator and glutamate release inhibitor in cultured rat cerebellar neurons and in gerbil global brain ischemia.},
  author={Paul G. Lysko and Christine L. Webb and Tian-li Yue and Jiali Gu and G{\"u}nter Feuerstein},
  journal={Stroke},
  year={1994},
  volume={25 12},
  pages={2476-82}
}
BACKGROUND AND PURPOSE Studies examining the role of tetrodotoxin-sensitive ion channels in hypoxic-ischemic neuronal damage have concluded that sodium influx is an important initiating event. We examined the neuroprotectant effect of tetrodotoxin on both cultured cerebellar neurons and on CA1 hippocampal neurons of gerbils exposed to brain ischemia. METHODS We studied neuroprotective mechanisms using cultured rat cerebellar granule cells exposed to veratridine, which induced cytotoxicity… CONTINUE READING
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Endothelin receptors in neural systems

  • PG Lysko, P. Nambi
  • Methods Neurosci
  • 1993

Neuroprotective mechanism of (+)SKF 10,047 in vitro and in gerbil global brain ischemia

  • PG Lysko, Yue T-L, Gu J-L, G Feuerstein
  • Stroke
  • 1992

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