Neuroprotective effects of reactive oxygen species mediated by BDNF-independent activation of TrkB.

@article{Huang2012NeuroprotectiveEO,
  title={Neuroprotective effects of reactive oxygen species mediated by BDNF-independent activation of TrkB.},
  author={Yang Huang and James O. McNamara},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2012},
  volume={32 44},
  pages={15521-32}
}
Reactive oxygen species (ROS) have diverse biological consequences in the mammalian CNS, but the molecular targets mediating these pleiotropic effects are incompletely understood. Like ROS, the neurotrophin receptor, TrkB receptor tyrosine kinase, has diverse effects in the developing and mature mammalian brain. Our discovery that zinc can transactivate TrkB, together with the finding that ROS can trigger zinc release from cytosolic zinc binding proteins, led us to hypothesize that ROS can… CONTINUE READING
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