Neuroprotective effects of propofol in models of cerebral ischemia: inhibition of mitochondrial swelling as a possible mechanism.

@article{Adembri2006NeuroprotectiveEO,
  title={Neuroprotective effects of propofol in models of cerebral ischemia: inhibition of mitochondrial swelling as a possible mechanism.},
  author={Chiara Adembri and Luna Venturi and A. Meziane Tani and Alberto Chiarugi and Elena Gramigni and Andrea Cozzi and Tristano Pancani and Raffaele A De Gaudio and Domenico Edoardo Pellegrini-Giampietro},
  journal={Anesthesiology},
  year={2006},
  volume={104 1},
  pages={80-9}
}
BACKGROUND Propofol (2,6-diisopropylphenol) has been shown to attenuate neuronal injury in a number of experimental conditions, but studies in models of cerebral ischemia have yielded conflicting results. Moreover, the mechanisms involved in its neuroprotective effects are yet unclear. METHODS The authors evaluated the neuroprotective effects of propofol in rat organotypic hippocampal slices exposed to oxygen-glucose deprivation, an in vitro model of cerebral ischemia. To investigate its… CONTINUE READING