Neuroprotective effects of phenylenediamine derivatives independent of an antioxidant pathway in neuronal HT22 cells.

Resistance to oxidative stress often determines neuronal survival in the brain. Thus, antioxidants are supposed to be promising neuroprotective compounds against neurodegenerative diseases. For example, N,N'-diphenyl-p-phenylenediamine (DPPD) reportedly exerts cytoprotective effects against oxidative stress possibly by acting as an antioxidant. DPPD can… CONTINUE READING