Neuroprotective effects of overexpressed cyclophilin B against Aβ-induced neurotoxicity in PC12 cells.

@article{Oh2011NeuroprotectiveEO,
  title={Neuroprotective effects of overexpressed cyclophilin B against Aβ-induced neurotoxicity in PC12 cells.},
  author={Yoojung Oh and Eun Young Kim and Yeonghwan Kim and Jizi Jin and Byung Kwan Jin and Geon-Ho Jahng and Min Hyung Jung and Chan Dong Park and Insug Kang and Joohun Ha and Wonchae Choe},
  journal={Free radical biology & medicine},
  year={2011},
  volume={51 4},
  pages={905-20}
}
Accumulated amyloid-β (Aβ) is a well-known cause of neuronal apoptosis in Alzheimer disease and functions in part by generating oxidative stress. Our previous work suggested that cyclophilin B (CypB) protects against endoplasmic reticulum (ER) stress. Therefore, in this study we examined the ability of CypB to protect against Aβ toxicity. CypB is present in the neurons of rat and mouse brains, and treating neural cells with Aβ(25-35) mediates apoptotic cell death. Aβ(25-35)-induced neuronal… CONTINUE READING