Neuroprotective effects of oestrogen against oxidative toxicity through activation of G-protein-coupled receptor 30 receptor.

@article{Liu2011NeuroprotectiveEO,
  title={Neuroprotective effects of oestrogen against oxidative toxicity through activation of G-protein-coupled receptor 30 receptor.},
  author={Shui-Bing Liu and Jie Han and Nan Zhang and Z. T. Tian and Xu-bo Li and Minggao Zhao},
  journal={Clinical and experimental pharmacology & physiology},
  year={2011},
  volume={38 9},
  pages={577-85}
}
1. 17-β-oestradiol (E2) plays a critical role in neuroprotection through both genomic and non-genomic mechanisms. The aim of the present study was to investigate the role of G-protein-coupled receptor 30 (GPR30), a new kind of oestrogen receptor, in the neuroprotection against oxidative insult. 2. The neuroprotection evoked by GPR30 stimulation was examined in cultured cortical neurons. Hoechst 33258/propidium iodide double staining, flow cytometric analysis and western blotting were applied to… CONTINUE READING