Neuroprotective effects of nitidine against traumatic CNS injury via inhibiting microglia activation.

@article{Yuan2015NeuroprotectiveEO,
  title={Neuroprotective effects of nitidine against traumatic CNS injury via inhibiting microglia activation.},
  author={Yimin Yuan and Feng Zhu and Yingyan Pu and Dan Wang and Aijun Huang and Xin Hu and Shangyao Qin and Xiu Bin Sun and Zhi-da Su and Cheng He},
  journal={Brain, behavior, and immunity},
  year={2015},
  volume={48},
  pages={287-300}
}
Glial cell response to injury has been well documented in the pathogenesis after traumatic brain injury (TBI) and spinal cord injury (SCI). Although microglia, the resident macrophages in the central nervous system (CNS), are responsible for clearing debris and toxic substances, excessive activation of these cells will lead to exacerbated secondary damage by releasing a variety of inflammatory and cytotoxic mediators and ultimately influence the subsequent repair after CNS injury. In fact… CONTINUE READING
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