Neuroprotective effects of naturally occurring polyphenols on quinolinic acid‐induced excitotoxicity in human neurons

@article{Braidy2010NeuroprotectiveEO,
  title={Neuroprotective effects of naturally occurring polyphenols on quinolinic acid‐induced excitotoxicity in human neurons},
  author={Nady Braidy and Ross Grant and Seray Adams and Gilles J. Guillemin},
  journal={The FEBS Journal},
  year={2010},
  volume={277}
}
Quinolinic acid (QUIN) excitotoxicity is mediated by elevated intracellular Ca2+ levels, and nitric oxide‐mediated oxidative stress, resulting in DNA damage, poly(ADP‐ribose) polymerase (PARP) activation, NAD+ depletion and cell death. We evaluated the effect of a series of polyphenolic compounds [i.e. epigallocatechin gallate (EPCG), catechin hydrate, curcumin, apigenin, naringenin and gallotannin] with antioxidant properties on QUIN‐induced excitotoxicity on primary cultures of human neurons… 
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