Neuroprotective effects of miR-142-5p downregulation against isoflurane-induced neurological impairment

  title={Neuroprotective effects of miR-142-5p downregulation against isoflurane-induced neurological impairment},
  author={Cuili Xie and H. Wang and Yanmin Zhang and Yanhua Wei},
  journal={Diagnostic Pathology},
  • Cuili Xie, H. Wang, +1 author Yanhua Wei
  • Published 2020
  • Medicine
  • Diagnostic Pathology
  • Background Isoflurane can lead to neuron damage to the developing brain, resulting in learning and memory disability. The aim of this study was to investigate the role of miR-142-5p on isoflurane-induced neurological impairment. Methods The Morris water maze (MWM) test was performed to evaluate spatial learning and memory of rats. The expression level of miR-142-5p was measured using qRT-PCR. MTT assay was used to calculate the viability of hippocampal neuronal cells. The cell apoptosis was… CONTINUE READING


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