Neuroprotective effects of melanocortins in experimental spinal cord injury. An experimental study in the rat using topical application of compounds with varying affinity to melanocortin receptors

@article{Sharma2005NeuroprotectiveEO,
  title={Neuroprotective effects of melanocortins in experimental spinal cord injury. An experimental study in the rat using topical application of compounds with varying affinity to melanocortin receptors},
  author={Hari Shanker Sharma and A. Skottner and Torbj{\"o}rn Lundstedt and Mar{\'i}a Fl{\"a}rdh and Lars Wiklund},
  journal={Journal of Neural Transmission},
  year={2005},
  volume={113},
  pages={463-476}
}
The possibility that local administration of low molecular weight non-peptide compounds with varying affinities at melanocortin receptors in the spinal cord will influence pathophysiological outcome of spinal cord injury (SCI) was examined in a rat model. Five new Melacure compounds ME10092, ME10354, ME10393, ME10431 and ME10501 were used in this investigation. Each compound was dissolved in saline and tested at 3 different doses, i.e. 1 µg, 5 µg and 10 µg total dose in 10 µl applied topically… CONTINUE READING