Neuroprotective effects of lipoxygenase inhibitors against ischemic injury in rat hippocampal slice cultures

@article{Arai2001NeuroprotectiveEO,
  title={Neuroprotective effects of lipoxygenase inhibitors against ischemic injury in rat hippocampal slice cultures},
  author={Kenzo Arai and Nobuyoshi Nishiyama and Norio Matsuki and Yuji Ikegaya},
  journal={Brain Research},
  year={2001},
  volume={904},
  pages={167-172}
}
Using organotypic cultures of rat hippocampal slices, we investigated the possible involvement of arachidonate cascades in neuronal death following ischemic insult. Oxygen/glucose deprivation-induced neuronal damage was efficiently attenuated by various inhibitors of lipoxygenase, whereas cyclooxygenase inhibitors were less effective. Interestingly, 5- and 12-lipoxygenases are likely to separately mediate ischemic injury in the hippocampus. The present study will provide novel therapeutic… CONTINUE READING

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References

Publications referenced by this paper.
Showing 1-10 of 19 references

Brain Research

Arai
Brain Research • 2001

Genes encoding multiple genase inhibition

G Y Molloy, M Rattray, R J Williams
J. Neurochem • 2001

Koistinaho, Piroxicam and NS-398 rescue neurones from hypoxia

Selectivity Ery
Trends Pharmacol. Sci • 1999

Hormonal control of programmed cell death

W Kiess, B Gallaher, +3 authors B K Siesjo
Brain cortical apoptosis Eur. J. Endocrinol • 1998

inhibition prevents delayed death of CA1 hippocampal neurons Needleman, C.B. Saper, Distribution and characterization of cyclofollowing global ischemia

C D Breder, W L Smith, A Raz, J Masferrer, K Seibert
Proc. Natl. Acad. Sci. USA 95 • 1998
View 1 Excerpt

fibers after epileptiform activities via L-type Ca channel activation characterization of a coactivator for the steroid hormone receptor in vitro

J. Neurosci. Science • 1995

Neurochir. Suppl. (Wien)

Neurochir. Suppl. (Wien) • 1993