Neuroprotective effects of insulin-like growth factor-binding protein ligand inhibitors in vitro and in vivo.

@article{Mackay2003NeuroprotectiveEO,
  title={Neuroprotective effects of insulin-like growth factor-binding protein ligand inhibitors in vitro and in vivo.},
  author={Kenneth B Mackay and Sarah A. Loddick and Gregory S Naeve and Alicia M. Vana and Gail M Verge and Alan C. Foster},
  journal={Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism},
  year={2003},
  volume={23 10},
  pages={1160-7}
}
The role of brain insulin-like growth factors (IGFs) and IGF binding proteins (IGFBPs) in neuroprotection was further investigated using in vitro and in vivo models of cerebral ischemia by assessing the effects of IGF-I, IGF-II, and high affinity IGFBP ligand inhibitors (the peptide [Leu24, 59, 60, Ala31]hIGF-I (IGFBP-LI) and the small molecule NBI-31772 (1-(3,4-dihydroxybenzoyl)-3-hydroxycarbonyl-6, 7-dihydroxyisoquinoline), which pharmacologically displace and elevate endogenous, bioactive… CONTINUE READING