Neuroprotective effects of high-dose vs low-dose melatonin after blunt sciatic nerve injury

@article{Shokouhi2007NeuroprotectiveEO,
  title={Neuroprotective effects of high-dose vs low-dose melatonin after blunt sciatic nerve injury},
  author={Ghaffar Shokouhi and R Shane Tubbs and Mohammadali M Shoja and Shahram Hadidchi and Amir Ghorbanihaghjo and Leila Roshangar and Ramin M. Z. Farahani and Mehran Mesgari and Walter Jerry Oakes},
  journal={Child's Nervous System},
  year={2007},
  volume={24},
  pages={111-117}
}
Melatonin, the secretory product of the pineal gland, has potent antioxidant properties. The aim of this study was to compare the effects of low-dose (10 mg/kg) vs high-dose (50 mg/kg) melatonin on early lipid peroxidation levels and ultrastructural changes in experimental blunt sciatic nerve injury (SNI). We believe this to be the first study to assess the dose-dependent neuroprotective effects of melatonin after a blunt peripheral nerve injury. Rats were randomly allocated into 5 groups of 10… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-9 of 9 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 40 references

Similar Papers

Loading similar papers…