Neuroprotective effects of flavonoids on hypoxia-, glutamate-, and oxidative stress–induced retinal ganglion cell death

@inproceedings{Nakayama2011NeuroprotectiveEO,
  title={Neuroprotective effects of flavonoids on hypoxia-, glutamate-, and oxidative stress–induced retinal ganglion cell death},
  author={Mao Nakayama and Makoto Aihara and Yi-Ning Katherine Chen and Makoto Araie and Kaori Tomita-Yokotani and Tsukasa Iwashina},
  booktitle={Molecular vision},
  year={2011}
}
PURPOSE This study was conducted to investigate the effect of flavonoids, a major family of antioxidants contained in foods, on retinal ganglion cell (RGC) death induced by hypoxia, excessive glutamate levels, and oxidative stress. Moreover, to assess the structure-activity relationships of flavonoids, three types of flavonoids with different numbers of hydroxyl groups and varieties of sugar chains were studied. METHODS Three kinds of flavonoids-nicotiflorin, rutin, and quercitrin-were used… CONTINUE READING
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