Neuroprotective effects of flavones on hydrogen peroxide-induced apoptosis in SH-SY5Y neuroblostoma cells.

@article{Kang2004NeuroprotectiveEO,
  title={Neuroprotective effects of flavones on hydrogen peroxide-induced apoptosis in SH-SY5Y neuroblostoma cells.},
  author={Sam Sik Kang and Ji Yeon Lee and Yoo Keum Choi and Gap Seok Kim and Byung Hee Han},
  journal={Bioorganic & medicinal chemistry letters},
  year={2004},
  volume={14 9},
  pages={2261-4}
}
Neuroprotective effects of flavones were examined. Luteolin and apigenin exhibited neuroprotection against oxidative stress-induced cell death in SH-SY5Y cells. Free radical scavenging activity and neuroprotection assays revealed that flavones exerted their neuroprotective effects via the direct interaction with the apoptotic caspase pathway independently of their antioxidant activity.