Neuroprotective effects of estrogens following ischemic stroke.

@article{Suzuki2009NeuroprotectiveEO,
  title={Neuroprotective effects of estrogens following ischemic stroke.},
  author={Shotaro Suzuki and Candice M Brown and Phyllis M. Wise},
  journal={Frontiers in neuroendocrinology},
  year={2009},
  volume={30 2},
  pages={201-11}
}
Our laboratory has investigated whether and how 17beta-estradiol (E(2)) protects the brain against neurodegeneration associated with cerebrovascular stroke. We have discovered that low, physiological concentrations of E(2), which are strikingly similar to low-basal circulating levels found in cycling mice, dramatically protect the brain against stroke injury, and consequently revealed multiple signaling pathways and key genes that mediate protective action of E(2). Here we will review the… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 74 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 113 references

Age-dependent increase in ischemic brain injury in wild-type mice and in mice lacking the inducible nitric oxide synthase gene.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism • 1999
View 5 Excerpts
Highly Influenced

Delayed reduction of ischemic brain injury and neurological deficits in mice lacking the inducible nitric oxide synthase gene.

The Journal of neuroscience : the official journal of the Society for Neuroscience • 1997
View 4 Excerpts
Highly Influenced

Inducible nitric oxide synthase gene expression in brain following cerebral ischemia.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism • 1995
View 16 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…