Neuroprotective effects of epoxyeicosatrienoic acids.

@article{Wang2018NeuroprotectiveEO,
  title={Neuroprotective effects of epoxyeicosatrienoic acids.},
  author={Lan-ping Wang and Gan Luo and Longfei Zhang and Hui-Xia Geng},
  journal={Prostaglandins & other lipid mediators},
  year={2018},
  volume={138},
  pages={
          9-14
        }
}
Eicosatrienoic acids (EETs) are a class of intermediates produced during arachidonic acid metabolism mediated by cytochrome P450 epoxygenases that exert multiple physiological effects on the nervous system. EETs promote three metabolic processes, including esterification, hydrolysis and degradation or extension. EETs are hydrolyzed by soluble epoxide hydrolase (sEH) to form corresponding diols, thereby reducing their biological activity. Strategies regulating sEH expression or activity affect… CONTINUE READING
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