Neuroprotective effects of diazepam, carbamazepine, phenytoin and ketamine after pilocarpine-induced status epilepticus.

@article{Cunha2009NeuroprotectiveEO,
  title={Neuroprotective effects of diazepam, carbamazepine, phenytoin and ketamine after pilocarpine-induced status epilepticus.},
  author={Alexandra Olimpio Siqueira Cunha and M{\'a}rcia Renata Mortari and Jos{\'e} Luiz Liberato and Wagner Ferreira Dos Santos},
  journal={Basic & clinical pharmacology & toxicology},
  year={2009},
  volume={104 6},
  pages={470-7}
}
Cell damage and spatial localization deficits are often reported as long-term consequences of pilocarpine-induced status epilepticus. In this study, we investigated the neuroprotective effects of repeated drug administration after long-lasting status epilepticus. Groups of six to eight Wistar rats received microinjections of pilocarpine (2.4 mg/microl, 1 microl) in the right dorsal hippocampus to induce a status epilepticus, which was attenuated by thiopental injection (35 mg/kg, i.p.) 3 hrs… CONTINUE READING
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Effect on epileptogenesis

  • HM Capella, T. Lemos
  • 2006

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